Ole Gunnar Solskjaer and his side are in Serbia to face Partizan Belgrade in the Europa League on Thursday evening.
Partizan currently sit fifth in the Serbian SuperLiga with seven wins from the opening 11 games, while also remaining undefeated in their last 11 home games against European opposition.
The two sides currently occupy the desired top two spots in Group L, sitting on four points apiece following a win and a draw in their respective opening fixtures.
Thursday’s fixture is arguably Manchester United’s toughest in the group stages and three points would go a long way to securing qualification to the knockout stages.
talkSPORT will have all the action live and here is how you can tune in.
The game will get under way at 5:55pm on Thursday, October 24 and talkSPORT will bring you all the build-up plus live commentary from Stadion FK Partizan.
To tune in, click here for the live stream or click the radio player below.
You can also listen through the talkSPORT App, on DAB Digital Radio or on MW 1053 or 1089.
Thursday’s clash will mark the first time the two sides face each other since the 1965/66 European Champion Clubs’ Cup semi-final, which Partizan win 2-1 on aggregate.
Partizan got their Europa League campaign off to a start with a 2-2 draw at home v AZ Alkmaar before winning 2-1 in Astana.
Meanwhile, United got the ball rolling with a 1-0 against Astana at Old Trafford with a Mason Greenwood goal before being held to a goalless draw against AZ Alkmaar at The Hague.
Manchester United will welcome Partizan to Old Trafford on November 7 for match day 4 of the Europa League group stages.
Diogo Dalot confirmed he is sidelined with an injury sustained in the defeat to Newcastle, while Axel Tuanzebe picked up an injury in the warm-up against Liverpool and will also miss out on Thursday.
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Luke Shaw, Nemanja Matic, Paul Pogba and Jesse Lingard were also ruled out of the match with the league leaders, along with long-time absentee Eric Bailly, all of whom are expected to miss the Europa League clash in Serbia.
Aaron Wan-Bissaka and Anthony Martial all returned from injury to face Liverpool while David de Gea overcame an injury scare to start between the sticks in the 1-1 draw on Sunday and they are all available to travel as well as Phil Jones who made the bench after proving his fitness.
Academy prospect, James Garner, was not involved with the Under-23’s game against Swansea City on Monday so that he could be in contention, with youngsters Brandon Williams, Tahith Chong, Angel Gomes and Mason Greenwood, with the latter recently signing a new long-term deal at the club, are also tipped to travel having featured heavily in The Europa League so far this season.
As for Partizan the only long-term injury is former Liverpool and Fulham winger Lazar Markovic who is expected to be out until the end of the year.
Partizan Belgrade: Stojkovic, Nemanja Miletic, Ostojic, Strahinja Pavlovic, Urosevic, Natcho, Zdjelar, Tosic, Soumah, Asano, Umar.
Subs: Vujacic, Lazar Pavlovic, Ivanovic, Scekic, Brezancic, Filip Stevanovic, Nemanja Stevanovic.
Manchester United: Romero, Jones, Maguire, Rojo, Wan Bissaka, McTominay, Garner, Williams, Mata, Lingard, Martial.
Subs: Lindelof, Rashford, Grant, Andreas Pereira, Fred, James, Greenwood.
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